Document Details

Document Type : Project 
Document Title :
A study of some properties Alkimu vital physiological, behavioral and neurological effect of MTBI in laboratory rats
دراسة لبعض الخصائص الكيمو حيوية والسلوكية والفسيولوجية العصبية لتأثير مادة MTBIفي الفئران المعملية
 
Document Language : Arabic 
Abstract : Been through the study of the current study, toxic effect of the substance MTBE added to unleaded gasoline and used in the Kingdom of Saudi Arabia and some other countries, in order to improve the ratio of octane to increase the combustion of gasoline. Recent research has shown that the substance of MTBE have an adverse effect on the environment and human health. The objectives of the current study, toxic effect of study material for MTBE on motor behavior and functions of the liver, kidney and some neurotransmitters (dopamine and Alnurabnfren and serotonin). The results of the current study showed that chronic exposure (repeated) of gasoline has been no significant changes in the elements of motor behavior for a walk and Perching and the number of times lifting up and the number of boxes that have been made. While the lack of moral only happened in a period of latency, as well as an event significant decrease in the number of times the lift on the wall when compared to the lab group (III), presented to the gasoline mixture with the control group. It is clear from the results of the current study that chronic exposure (repeated) of gasoline has a dampening effect of motor activity. Mice also resulted in exposure to benzene in the study in both groups (second and third) to the significant increase in liver function in the content of each of the enzyme (SGPT) and (SGOT) and basal phosphatase and bilirubin. Where it is inhalation of gasoline any significant difference in kidney function at the level of creatinine (Creatinine). While led to a significant increase in the level of urea acid urea. When subjected mice to inhalation of MTBE-blended gasoline substance both in the gas station or in the lab (6 hours / day / 5 days a week for three months) led to a significant decrease in the content of each of the Alnorabeveran, dopamine and serotonin. Say it Alnorabeveran content in all regions of the brain regions studied except the striatum and cortex as well as the content of the lack of dopamine in all brain regions studied except the cerebral cortex only. In the case of serotonin has less content in the areas of the body plan and under the hypothalamus and midbrain, and hippocampus, while not causing any change significant in the other regions studied. This lack of moral content in Alnorabeveran, dopamine and serotonin could be a result of the impact of neurological toxic to this article, thus affecting the A receptors of a substance that GABA plays an important role in the incidence of this lack of moral content of these neurotransmitters. 
Publishing Year : 1425 AH
2005 AD 
Sponsor Name : kau 
Sponsorship Year : 1425 AH
2005 AD 
Added Date : Wednesday, April 30, 2008 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
منصور عطية الحازميalhazmi, mansour attiaInvestigatorDoctorate 

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