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Document Type |
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Project |
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Document Title |
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Ultrastructural alteraltions induced by IM injection of botulinum toxin(Botox)Influence of age, muscle fiber type and number of injections التغيرات التركيبية الدقيقة الناتجة عن الحقن بسم البوتيولينوم (بوتوكس) وعلاقتها بالعمر، نوع الألياف العضلية وعدد مرات الحقن |
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Subject |
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Ultrastructural alteraltions induced by IM injection of botulinum toxin(Botox)Influence of age, muscle fiber type and number of injections |
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Document Language |
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Arabic |
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Abstract |
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The list of indications for the clinical use of botulinum toxin (BOTOX) injection has widely expanded. Botox injections are used to control a large number of disorders, characterized by abnormal involuntary spasmodic muscle contractions. Examples include focal dystonia, dysfunction of extra-ocular muscles, alleviation of spasticity associated with cerebral palsy and Parkinsonism.
Recently, BOTOX injections are used in cosmetic and dermatological conditions, e.g. treatment of excessive sweating and correction of skin wrinkles. As the toxin-induced cure is temporary, patients need to receive more than one injection at timely intervals.
In view of such extensive use of botulinum toxin, it is critically important for clinicians to have a comprehensive understanding of the sequence of events when this toxin is injected into muscle. Such understanding should help clinicians determine the dose and the site of injection, in order to obtain better results and to avoid side effects.
The present research proposal involves examining the morphological alterations induced by IM injection of botulinum toxin in relation to four main aspects; 1) age, 2) muscle fiber type, 3) the muscle injected, and 4) the number of injections used.
The structural alterations will be examined at the light and electron microscopic levels. In addition, immunohistochemistry will be used to identify nerve terminal outgrowth and the formation of new neuro-muscular junctions. Such documentation should also deepen our understanding of nerve-muscle interactions. |
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Publishing Year |
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1428 AH
2007 AD |
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Added Date |
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Monday, June 28, 2010 |
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Researchers
| شريف محمد حسن | Hassan, Sherif Mohamed | Investigator | Doctorate | |
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