Document Details

Document Type : Project 
Document Title :
The Preventive and Therapeutic Role of Curcumin in Liver
الدور الوقائي و العلاجي للكركم في تليف الكبد
 
Subject : The Preventive and Therapeutic Role of Curcumin in Liver 
Document Language : Arabic 
Abstract : Chronic liver disease constitutes a major health problem in the Kingdom of Saudi Arabia. Hepatic fibrosis or cirrhosis is emerging as a treatable complication of chronic liver disease, following significant progress in understanding its underlying mechanisms. Efforts have focused on the hepatic stellate cells (HSC), as these cells can undergo, “activation” into proliferation and fibrogenic myofibroblast-like cells during liver injury. Disease-specific fibrogenic mechanisms have also include direct stimulation of stellate cell as by viral infections in hepatitis C and elevated leptin levels in non-alcoholic steatohepatitis (NASH). Antifibrotic therapies could become important in treating the millions of patients with chronic fibrosing liver disease. Curcumin the major polyphenolic compound in tumeric has been shown to attenuate hepatic damage. So, the present study was designed to assess the efficacy of curcumin intake in preventing thioacetamide-induced hepatic cirrhosis and to unravel the mechanism of its potential effect: is it a direct effect on HSC and collagen formation or an indirect effect by prevention of inflammation and necrosis. Four groups of rats will be used throughout this study. Group I (Control group) rats will receive the solvent at identical amount and duration. Liver cirrhosis will be induced in Groups II, III, and VI by thioacetamide (TAA; 200mg/kg, ip) twice weekly for 12 weeks. Group II (Cirrhosis group): untreated group. Group III (Prevention group): rats will receive curcumin (300 mg/kg/day, by gavage for 12 weeks) concomitantly with TAA. Group IV (Treatment group): rats will be given curcumin for 6 weeks after TAA discontinuation. Specimens from the liver will be processed for paraffin sections and stained with Hx&E and Masson Trichrome stain. Alpha smooth muscle actin expressed immunohistochemically by HSC will be considered a marker of their activation to myofibroblast. Nitrotyrosine level will be assessed in liver as a measure of oxidative stress. Image analyzer will be used to analyze the results morphometrically. Also, statistical analysis of the results will be determined by ANOVA test. 
Publishing Year : 1428 AH
2007 AD 
Sponsor Name : King Abdulaziz University 
Sponsorship Year : 1428 AH
2007 AD 
Added Date : Monday, June 28, 2010 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
أميرة حسن الحجاج علي الحجاجيEl-Haggagy, Amira AliInvestigatorDoctorate 

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