Document Details

Document Type : Project 
Document Title :
Altered pancreatic development in the offspring of pregnant and lactating rats given low protein diet.
تطور البنكرياس المعدل فى نسل حوامل و مرضعات الفئران معطيا غذاء ناقص البروتين
 
Subject : Altered pancreatic development in the offspring of pregnant and lactating rats given low protein diet. 
Document Language : Arabic 
Abstract : Human epidemiologic and experimental animal studies suggest strongly that prenatal and early postnatal nutrition influence adult susceptibility to diet-related chronic disease. Type 2 diabetes, which has dramatically increased during the last decade, normally results from a combination of pancreatic beta cell dysfunction and insulin resistance. One of the most recent risk factors identified for type 2 diabetes is a sub-optimal fetal and neonatal environment. So the present work is conducted to study the effect of low protein diet, a common problem in many countries, on the endocrine pancreas of the offspring of pregnant and lactating rats. In this study, wister rats will be divided into 3 groups before mating according to the diets given. Group І: control taking commercial diet. Group ІІ: will be given standard diet. Group ІІІ: will be maintained on low protein diet. This diet will be maintained for 4 weeks. After induction of pregnancy between male and female rats, the pregnant females will be divided into the three previous groups. These diets will be given through the whole period of pregnancy at the end of which laparotomy will be done for some of the pregnant rats. The remaining pregnant rats will be allowed to deliver spontaneously and lactate their litters until weaning. The lactating rats are also divided into 3 groups. Group IV is control. Group V is still on standard diet. Group VІ is further divided into group a) which will continue on low protein diet and group b) will be given standard diet. After 3 weeks scarification of some of the neonates will be done. The rest of the neonates will be having access to stock diet till 8weeks old. Study of the pancreases of the litters at birth and after weaning will be done using morphometric analysis, immunostaining for detecting insulin. Blood samples will be taken from the mother and offspring to determine glucose level. Plasma insulin level will be measured in the offspring. IGF-I will be evaluated in the serum of the offspring. 
Publishing Year : 1428 AH
2007 AD 
Sponsor Name : King Abdulaziz University 
Sponsorship Year : 1428 AH
2007 AD 
Added Date : Tuesday, June 29, 2010 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
سمر محمد السقافAl.Saggaf, Samar MohammedInvestigatorDoctorate 

Files

File NameTypeDescription
 27180.docx docx 

Back To Researches Page