Document Details

Document Type : Project 
Document Title :
Investigation of CCR5 Δ32 and CCR5 59029 polymorphism in hepatitis C virus infected patients in Saudi population
البحث عن طفرة في أحد المستقبلات للكيموكاينز في مرضى الكبد الوقائي نوع (س) في المجتمع السعودي وعلاقة هذه الطفرة بتقدم المرض أو تأثيره في العلاج.
 
Subject : Investigation of CCR5 Δ32 and CCR5 59029 polymorphism in hepatitis C virus infected patients in Saudi population 
Document Language : Arabic 
Abstract : Hapitatis C virus (HCV) is the leading cause of chronic liver disease worldwide. Hapitatis C virus (HCV) causes parenteral-transmitted acute hepatitis, chronic active hepatitis, cirrhosis, and possible liver cancer. Immunogenetic factors may play a role in determining the susceptibility of an individual to viral infection. Chemokines or chemotactic cyto-kines are small protein molecules produced by a variety of cells and are an important component of the inflammatory process. Chemokine receptors are cell surface proteins that bind small peptides called chemokines. Some chemokine receptors have a role in infectious disease susceptibility or pathogenesis. One of them is CCR5, CCR5 promotor polymorphisms are known to be associated with HIV infection. A 32-base pair deletion of the CCR5 gene (CCR5 Δ32) protects against HIV infection because the frame shift leads to a truncated protein not expressed on the cell surface. CCR5 Δ32 also delays progression in heterozygous HIV-infected patients and improves responses to antiretroviral therapy. Another polymorphism at base pair 59029 in the CCR5 promotor was detected which has a role in HIV progression. Recent studies had showed a correlation between HCV disease and these polymorphisms. The aim of the project is to investigate these polymorphisms genotype distribution in Hepatitis C virus none treated patients and treated patients, and whether it affects the progression of HCV disease. 
Publishing Year : 1427 AH
2006 AD 
Sponsor Name : King Abdulaziz University 
Sponsorship Year : 1427 AH
2006 AD 
Added Date : Tuesday, June 29, 2010 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
فدوى مزاحم آل غالبAal-Ghalib, Fadwah MozahemInvestigatorDoctorate 

Files

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 27188.docx docx 

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