Document Details

Document Type : Project 
Document Title :
Postantibiotic effects of different antimicrobial agents on gram-negative clinical isolates.
تأثير أنواع مختلفة من مضادات الميكروبات ، بعد ازالتها من الوسط، علي عزلات إكلينيكية سالبية الجرام
 
Subject : Postantibiotic effects of different antimicrobial agents on gram-negative clinical isolates. 
Document Language : Arabic 
Abstract : The term postantibiotic effect refers to a period of time after complete removal of an antibiotic during which there is no growth of the target organism. During intermittent dosing regimens, suprainhibitory levels of antibiotic are followed by subinhibitory levels that persist between doses. These subinhibitory levels which are defined as postantibiotic subinhibitory concentration effect could extend the postantibiotic effect. Both postantibiotic effects and postantibiotic subinhibitory concentration effects appear to be a feature of most antimicrobial agents and have been documented with a variety of common bacterial pathogens. They have increasingly become the focus of investigations designed to determine optimal dosing regimens for antimicrobial agents. Choosing the right dose and dosing interval may also be critical to achieving optimal clinical responses and preventing the emergence of resistant pathogens. An infection evoked by an organism susceptible to an antimicrobial agent with a significant postantibiotic effect and postantibiotic subinhibitory concentration effect may require administration for a longer time period as compared to an agent lacking this pattern. The antibiotic therapy is usually adopted, on the assumption that the drug concentrations at the site of infection reach the minimum bactericidal concentration, thus eliminating the virulence of the microorganisms by killing them. In contrast, although the microorganisms do not necessarily die, MICs can inhibit the growth of bacteria. In addition, some bacterial functions, virulence factors, and outer membrane protein components can be affected by the postantibiotic effects and postantibiotic subinhibitory concentration effects induced by different antibiotics. In the present study, the postantibiotic effects and postantibiotic subminimum inhibitory concentration effects of different antimicrobial agents on the regrowth of different types of clinical isolates will be studied. In addition, different virulence factors and the outer membrane proteins profiles of the tested isolates after postantibiotic effects of the used antimicrobial agents will be analyzed. 
Publishing Year : 1428 AH
2007 AD 
Sponsor Name : King Abkdulaziz University 
Sponsorship Year : 1428 AH
2007 AD 
Added Date : Tuesday, June 29, 2010 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
محمود عبدالمجيد يسYassien, Mahmoud ِAbdel MajeedInvestigatorDoctorate 

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